Originally a mission hospital, which developed from a clinic service, Mseleni Hospital is situated in a remote part of northern KwaZulu Natal. It is 60km from the border with Mozambique and provides Primary Health Care for 75,000 rural people.

It is a 184-bed hospital which is split into 6 wards (labour, female surgical, paediatrics, male, female medical and isolation wards). The hospital runs 8 clinics in a catchment area of 100 x 30km. It has a therapy department, a radiography department with x-ray and ultrasound machines, a pharmacy and a laboratory.